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Wikipedia - Nateglinide

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Nateglinide
Systematic (IUPAC) name
(R)-2-(4-isopropylcyclohexanecarboxamido)-3-phenylpropanoic acid
Identifiers
CAS number 105816-04-4
ATC code A10BX03
PubChem 60026
DrugBank APRD00593
Chemical data
Formula C19H27NO3 
Mol. mass 317.423 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 98%
Metabolism  ?
Half life 1.5 hours
Excretion  ?
Therapeutic considerations
Licence data

EU EMEA:link, US FDA:link
Pregnancy cat.

?
Legal status
Routes  ?


Nateglinide (INN, trade name Starlix) is a drug for the treatment of type 2 diabetes. Nateglinide was developed by the Swiss pharmaceutical company Novartis.

Nateglinide belongs to the meglitinide class of blood glucose-lowering drugs.

[edit] Pharmacology

Nateglinide lowers blood glucose by stimulating the release of insulin from the pancreas. It achieves this by closing ATP-dependent potassium channels in the membrane of the ß cells. This depolarizes the ß cells and causes voltage-gated calcium channels to open. The resulting calcium influx induces fusion of insulin-containing vesicles with the cell membrane, and insulin secretion occurs.

[edit] Dosage

Nateglinide is delivered in 60mg & 120mg tablet form.

[edit] External links

v • d • e
Oral anti-diabetic drugs and Insulin analogs (A10)
Insulin

Metformin# · Buformin‡ · Phenformin‡
Meglitinides/"glinides"
Nateglinide · Repaglinide · Mitiglinide
Analogs/other insulins
Other
Amylin analog
SGLT2 inhibitor
Other
Retrieved from "http://starlix.legalview.info/wikipedia/Nateglinide/"

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Nateglinide".

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